Targeted protein degradation: elements of PROTAC design
نویسندگان
چکیده
منابع مشابه
Structural basis of PROTAC cooperative recognition for selective protein degradation
Inducing macromolecular interactions with small molecules to activate cellular signaling is a challenging goal. PROTACs (proteolysis-targeting chimeras) are bifunctional molecules that recruit a target protein in proximity to an E3 ubiquitin ligase to trigger protein degradation. Structural elucidation of the key ternary ligase-PROTAC-target species and its impact on target degradation selectiv...
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ژورنال
عنوان ژورنال: Current Opinion in Chemical Biology
سال: 2019
ISSN: 1367-5931
DOI: 10.1016/j.cbpa.2019.02.022